Researchers confine mature cells to turn them into stem cells

Stem cells are the blank slate on which all specialised cells in our bodies are built and they are the foundation for every organ and tissue in the body. Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) and the FIRC Institute of Molecular Oncology… Continue reading Researchers confine mature cells to turn them into stem cells

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Engineered cancer cells can fight primary and metastatic cancer

What if cancer cells could be re-engineered to turn against their own kind?  A new study led by researchers from Brigham and Women's Hospital : The power of gene editing to take a critical step toward using cancer cells to kill cancer. The reports were promising results in preclinical models across multiple types of cancer… Continue reading Engineered cancer cells can fight primary and metastatic cancer

Discovery unlocks secrets behind cancer drug resistance

 University of Otago research provides insights into an underlying mechanism that could explain why new cancer therapies to help treat metastatic melanoma do not always work on patients, paving the way for predicting which patients will benefit from certain drugs. Their findings shed much needed light on why new immune checkpoint inhibitor therapies such as… Continue reading Discovery unlocks secrets behind cancer drug resistance

Off/on switch for DNA repair protein

Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage. The authors say they hope this discovery research will help identify new therapies for ovarian cancer. While the human genome is constantly damaged, cells have proteins that detect… Continue reading Off/on switch for DNA repair protein

New type of lung cancer

Researchers have discovered a new kind of small-cell lung cancer (SCLC). The discovery paves the way for developing personalized medicine approaches to target this previously unnoticed form of the disease. "Cancer is not one thing, it's actually hundreds of distinct diseases." This common refrain helps explain the frustrating experience oncologists have in testing a promising… Continue reading New type of lung cancer

Fluorescent molecules reveal how cancer cells are inhibited

Researchers from Lund University, Sweden has developed a fluorescent variant of a molecule that inhibits cancer stem cells, which has enabled the researchers to  Capturing images of when the molecule enters a cell using cell-biological methods to successfully describe how and where the molecule counteracts the cancer stem cells.   However, Salinomycin is a molecule… Continue reading Fluorescent molecules reveal how cancer cells are inhibited

Why older people respond poorly to cancer treatment

Researchers may have found a group of immune cells that increase in number with age but are too worn out to fight diseases. The accumulation of dysfunctional virtual memory T cells, in addition to the loss of true naïve T cells this may explain why older people have reduced immune responses to cancer and vaccines,… Continue reading Why older people respond poorly to cancer treatment